Table 1 –
Study overview.
| Article | Diagnostic imaging modality | Study type | Population | Sample size | Ground truth | Length measurements (cm) | Correlation (r) | Significance (P-value) |
|---|---|---|---|---|---|---|---|---|
| Nightingale 19913 | BaFT | Retrospective Total small intestine length |
Varying pathologies (e.g., Crohn’s, radiation enteritis) with small bowel anastomosis and residual small intestine length <200 cm | 18 | Surgical measure | <200 | 0.72 | <0.01 |
| Shatari 20048 | BaFT | Retrospective Total small intestine length |
Patients with Crohn’s disease Median age: 39 y |
22 | Surgical measure | - | 0.70 | <0.01 |
| Lodwick 201611 | BaFT | Retrospective Total small intestine length |
Patients with SBS undergoing intestinal lengthening Mean age: 3.9 y |
13 | Surgical measure |
Radiographic median: 77 (29–142) Surgical median: 69 (21–170) |
0.93 | <0.01 |
| Velazco 201733 | BaFT | Retrospective Total small intestine length |
Children with SBS and severe intestinal failure Mean age: 0.8 y |
36 | Surgical measure |
Radiographic mean: 45 (11138) Surgical mean: 90 (18–270) |
0.43 | <0.01 |
| Cheng 20185 | BaFT, CTE | Prospective, single-center Total small intestine length |
Patients with SBS Median age: 43.8 y |
29 | Surgical measure |
BaFT mean: 51 (6–89) CTE mean: 76 (6–168) Surgical mean: 73.1 (5–160) |
BaFT: 0.71 CTE: 0.99 |
BaFT: < 0.01 CTE: < 0.01 |
| Migaleddu 200915 | US | Prospective, single-center Total small intestine length |
Patients with Crohn’s disease Mean age: 38 y |
47 | Endoscopic measure | - | 0.47 | <0.01 |
| Walldorf 201534 | US, btMRE | Prospective, Rodents Total colonic length |
Pathogen-free male balb/c mice Dextran sulfate sodium colitis (n = 36), healthy colon (n = 15) |
51 | Ex vivo measure | - |
US: - MRE: 0.53 |
US: > 0.05 MRE: < 0.05 |
| Dillman 201635 | US, MRE | Prospective, single-center Length of involved segment |
Children with newly diagnosed small bowel Crohn’s disease Mean age: 15.3 y |
29 | Additional imaging |
US mean: 8.8 (1.5–16.1) MRE mean: 14.6 (3.9–25.3) |
- | - |
| Broquet 201736 | CTE or MRE | Prospective, single-centert | Patients with ileocolonic Crohn’s disease Mean age: 36 y |
CTE: 19 MRE: 35 |
Ex vivo pathologic specimen |
Radiographic means*: 20.5 (2–73 cm) and 20 (3–90) Pathologic mean: 16.5 (2–75) |
0.76 | <0.01 |
| Sinha 201437 | MRE | Prospective, single-center Total small intestine length |
Patients with Crohn’s disease | 32 | Surgical measure |
Radiographic mean: 411 (156–797) Pathologic mean: 414 (156–797) |
0.98 | <0.05 |
| Wilson 201738 | MRE | Prospective, single-center and Rodents Total small intestine length |
Human: Patients who underwent routine MRE for clinical purposes Rodents: 10 C57BL/6 mice, age 10–12 wk |
Human: 15 Rodent: 10 |
Human: None Rodent:Ex vivo measure |
Human radiographic mean: 436 (203–912) Rodent radiographic mean: 36 (29–43) Rodent ex-vivo: 38 (34–43) |
0.63 | 0.02 |
BaFT = Barium follow-through; CTE = Computed Tomographic Enterography; US = Ultrasound; btMRE = benchtop magnetic resonance enterography.
*
Measurements performed by two different radiologists.