Table 1:
Plasma and tissue biochemistry in male VECadCre+Cc1fl/fl mice and their control littermates at 8 months of age
| VECadCre−Cc1+/+ | VECadCre+Cc1+/+ | VECadCre−Cc1fl/fl | VECadCre+Cc1fl/fl | |
|---|---|---|---|---|
| Hepatic TG (μg/mg protein) | 54.3 ± 2.9 | 59.9 ± 3.8 | 60.4 ± 4.8 | 54.4 ± 5.1 |
| Plasma TG (mg/dl) | 69.0 ± 3.9 | 70.2 ± 4.2 | 72.8 ± 4.5 | 69.8 ± 4.5 |
| Plasma IL-6 (pg/ml) | 3.7 ± 0.4 | 4.1 ± 0.3 | 7.2 ± 1.0 | 39.1 ± 4.8*†‡ |
| Plasma TNFα (pg/ml) | 12.5 ± 2.4 | 15.2 ± 2.9 | 10.6 ± 2.9 | 25.9 ± 3.1*†‡ |
| Hepatic NAD/NADH | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 3.3 ± 0.2*†‡ |
| Plasma 8-Isoprostane (pg/ml) | 5.1 ± 0.4 | 4.8 ± 0.3 | 5.6 ± 0.4 | 14.0 ± 0.6*†‡ |
| Plasma ALT (mU/ml) | 39.6 ± 2.4 | 31.8 ± 2.0 | 37.6 ± 5.0 | 66.9 ± 5.9*†‡ |
| Plasma AST (mU/ml) | 135.8 ± 10.9 | 112.2 ± 12.0 | 130.5 ± 15.2 | 186.9 ± 16.8*†‡ |
| Plasma MMP2 (ng/ml) | 836.1 ± 30.1 | 753.3 ± 22.1 | 774.3 ± 52.8 | 1279. ± 160.*†‡ |
| Plasma MMP13 (pg/ml) | 324.7 ± 69.2 | 263.1 ± 86.9 | 272.2 ± 83.1 | 295.2 ± 58.6 |
| Plasma TIMP1 (pg/ml) | 1.8 ± 0.2 | 1.5 ± 0.1 | 1.5 ± 0.2 | 3.3 ± 0.6*†‡ |
| Plasma endothelin1 (pg/ml) | 4.8 ± 1.2 | 4.5 ± 1.2 | 4.2 ± 1.3 | 8.8 ± 0.3*†‡ |
| Plasma SDF-1α (ng/ml) | 47.5 ± 2.4 | 45.4 ± 1.8 | 44.9 ± 3.6 | 82.8 ± 5.3*†‡ |
| Plasma PDGF-B (ng/ml) | 5.0 ± 0.3 | 4.7 ± 0.3 | 5.2 ± 0.3 | 12.8 ± 0.7*†‡ |
Male mice (8 months of age, n=5/genotype) were fasted from 5:00 p.m. until 11:00 a.m. the next morning before blood was drawn and tissues were excised. Values are expressed as mean ± SEM.
*
P<0.05 vs VECadCre–Cc1+/+,
†
P<0.05 vs VECadCre+Cc1+/+,
‡
P<0.05 vs VECadCre–Cc1fl/fl.