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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Eur Urol. 2023 May 19;84(1):127–137. doi: 10.1016/j.eururo.2023.04.020

Table 1 –

Novel loci associated with bladder cancer susceptibility a

SNP Band Position
(hg19)		 Gene
region		 Allele EA
frequency		 Studies
(n)		 Cases
(n)		 CTR
(n)		 OR
(95% CI)		 p
value		 Q b
EA Ref CTR Cases
Previously identified regions
rs2896518 4p16.3 1757559 TACC3, FGFR3 A G 0.21 0.23 9 13447 342 580 1.17 (1.13–1.22) 5.28×10−15 0.1901
rs2242652 5p15.33 1280028 CLPTM1L, TERT G A 0.80 0.82 9 13447 342 580 1.18 (1.14–1.24) 4.06×10−15 0.9181
rs10069690 1279790 C T 0.74 0.76 9 13447 342 580 1.16 (1.12–1.22) 1.54×10−14 0.7989
rs7937265 11p15.5 1947800 TNNT3, LSP1 G C 0.19 0.21 9 13447 342 580 1.13 (1.08–1.18) 1.10×10−8 0.1406
Newly identified regions
rs6910215 6p22.3 20783394 CDKAL1 C T 0.57 0.59 9 13447 342 580 1.10 (1.06–1.14) 1.05×10−8 0.6166
rs72826305 6p22.3 21826729 CASC15/LOC105374970 C T 0.34 0.37 9 13447 342 580 1.12 (1.08–1.16) 1.81×10−10 0.4132
rs2125484 7q36.3 155759638 LOC389602 G A 0.58 0.60 9 13447 342 580 1.11 (1.07–1.15) 1.42×10−9 0.7918
rs5003154 8q21.13 81986953 PAG1 C T 0.51 0.54 9 13447 342 580 1.11 (1.08–1.15) 1.15×10−10 0.8466
rs4743687 9q31.1 106856910 SMC2 C T 0.44 0.46 9 13447 342 580 1.10 (1.06–1.13) 2.05×10−8 0.0659
rs7076867 10q22.1 71582996 COL13A1 C T 0.95 0.96 9 13447 342 580 1.31 (1.22–1.41) 5.60×10−13 0.886
rs411482 19q13.33 49103447 SULT2B1-FAM83E C T 0.61 0.63 9 13447 342 580 1.13 (1.09–1.17) 1.16×10−12 0.3869
In smokers
rs1414253 9p21.3 21755630 LOC107987026, MTAP/CDKN2A A G 0.42 0.43
Ever smokers 8 9251 57124 1.14 (1.09–1.19) 1.23×10−8 0.5183
Current smokers c 6 3286 2802 1.27 (1.17–1.38) 9.37×10−9 0.1519

SNP = single-nucleotide polymorphism; EA = effect allele; Ref = reference; CTR = control; OR = odds ratio; CI = confidence interval

a

A fixed-effects meta-analysis by study was used to calculate the combined OR, 95% CI, and p trend for the EA, adjusted for age and array-specific principal components.

b

Cochran’s Q (measure of heterogeneity) p value.

c

rs10811586, which is in linkage disequilibrium with rs1414253 (D′ = 0.87, R2 = 0.72 in Europeans in 1000 Genomes), showed a slightly more significant association among current smokers (p = 2.29E-09).