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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Hypertension. 2023 May 1;80(7):1555–1567. doi: 10.1161/HYPERTENSIONAHA.123.20921

Figure 5. MALDI-MSI identification of upregulated omega-3 and omega-6 polyunsaturated fatty acids in KCNJ5 mutated APA compared with adjacent adrenal cortex.

Figure 5.

A, corresponding H&E-stained tissues of KCNJ5 mutated APA (Upper) or KCNJ5 wildtype APA (Lower) and adjacent adrenal gland used for MALDI-MSI. Outlined regions in black indicate APA tumor areas with positive CYP11B2 immunostaining. B-C, representative images showing spatial distribution of omega-3 polyunsaturated fatty acids (B) and omega-6 polyunsaturated fatty acids (C). Outlined regions in white represent the borders of the tissue section.