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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Mol Cell Cardiol. 2023 Apr 18;180:1–9. doi: 10.1016/j.yjmcc.2023.04.005

Figure 1. Ca2+ spark properties in permeabilized atrial cardiomyocytes.

Figure 1.

(A) Ca2+ spark frequency, (B) amplitude, (C) mass, and (D) leak. Figure panels shown with full range of values and a box bounding the 25th and 75th percentiles with median. N: Pitx2+/+ (vehicle) = 168 cells from 6 mice; Pitx2+/+ (ent-vert) = 36 cells from 2 mice; Pitx2+/− (vehicle) = 127 cells from 6 mice; Pitx2+/− (ent-vert) = 70 cells from 4 mice normalized to values from +/+ mice by day of experiment. Bonferroni-adjusted P values calculated using hierarchical clustering. (E) SR load measured by caffeine-induced Ca2+ transient amplitude. Individual values with mean ± SD.