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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Mol Cell Cardiol. 2023 Apr 18;180:1–9. doi: 10.1016/j.yjmcc.2023.04.005

Figure 5. Anti-arrhythmic efficacy of ent-verticilide on pacing-induced AF in both Pitx2+/+ and Pitx2+/− mice.

Figure 5.

(A, B) Incidence of inducible AF (Pitx2+/+: vehicle 54.6 % vs. ent-vert 45.5 %, Pitx2+/−: vehicle 100.0 % vs. ent-vert 65.0 %; non-sustained AF + sustained AF) by burst pacing stimulation in Pitx2+/+ and Pitx2+/− mice. Sustained AF was defined as continuous AF over 300 sec induced by any single pacing train. ent-Verticilide significantly reduced sustained AF compared to vehicle group in Pitx2+/− mice (vehicle 90.0 % vs. ent-vert 25.0 %, P<0.0001). (C, D) Summary of total AF burden in Pitx2+/+ and Pitx2+/− mice (N=11 and 20 mice, respectively). Data are mean ± SD. P values were obtained using Fisher’s exact test and Wilcoxon matched-pairs signed rank test.