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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Clin Pharmacol Ther. 2023 Apr 29;114(1):161–172. doi: 10.1002/cpt.2907

Table 2:

Predicted versus observed24–28 mean AUC, Cmax and clearancevalues of diclofenac in adults after iv and oral doses

Drug Age (yr) Sex Dosing regimen Ratio
AUC (mg/L*h) CL (L/h)
20-22 Female Single iv dose, 50 mg 0.88 1.16
Diclofenac ≥18 Mixed 30-minute iv infusion, 75 mg 1.08 0.97
Single iv dose, 75 mg 1.05 0.99
AUC (mg/L*h) Cmax (mg/L)
20-31 Male Single oral dose, 50 mg 1.40 1.23
20-44 Mixed 1.19 0.83
18.45 Mixed 1.23 0.81