Table 3.

Multivariable Analyses of sICAM-1 and ICH Outcomes

Covariate	Modified Rankin Score 4-6		Mortality
	OR (95% CI)	P value	OR (95% CI)	P value
sICAM-1, unadjusted	1.24 (1.03=−1.49)	0.02	1.38 (1.13-1.70)	0.002
sICAM-1, per SD#	1.34 (1.06-1.69)	0.013	1.53 (1.15-2.03)	0.03
	P value for interaction between sICAM-1 and treatment assignment = 0.97		P value for interaction between sICAM-1 and treatment assignment = 0.45
Recombinant Factor VII Arm (N= 348)
sICAM-1, unadjusted	1.30 (1.04-1.64)	0.02	1.49 (1.16-1.92)	0.002
sICAM-1, per SD*	1.36 (1.01-1.82)	0.04	1.66 (1.18-2.32)	0.003
Placebo Arm (N= 159)
sICAM-1, unadjusted	1.14 (0.84-1.55)	0.38	1.20 (0.85-1.70)	0.31
sICAM-1, per SD*	1.26 (0.86-1.83)	0.24	1.39 (0.79-2.46)	0.25

Abbreviations: CI, confidence interval; sICAM-1, soluble intercellular adhesion molecule-1; ICH, intracerebral hemorrhage; IVH, intraventricular hemorrhage; OR, odds ratio; PHE, perihematomal edema; SD, standard deviation.

^#Adjusted for age, sex, baseline ICH volume, baseline IVH volume, ICH location, baseline Glasgow Coma Scale, change in systolic blood pressure in 24 hours, treatment randomization, and time from symptom onset to administration of the study drug.

^*Adjusted for age, sex, baseline ICH volume, baseline IVH volume, ICH location, baseline Glasgow Coma Scale, and time from symptom onset to administration of the study drug.