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. Author manuscript; available in PMC: 2024 Jan 5.
Published in final edited form as: Mol Cancer Res. 2023 Jul 5;21(7):741–752. doi: 10.1158/1541-7786.MCR-22-0872

Fig. 5: High CCL5 and CCR5 expression in low grade esophageal cancers is associated with poor prognosis.

Fig. 5:

(A) Kaplan-Meier survival curve of the effect of CCL5 expression on esophageal cancer patient overall survival with grade 1 (well differentiated) + 2 (moderately differentiated) tumors. (B) Kaplan-Meier survival curve of the effect of CCL5 expression on esophageal cancer patient overall survival with grade 3 (poorly differentiated) tumors. (C) Kaplan-Meier survival curve of the effect of CCR5 expression on dataset analyzed for A. (D) Kaplan-Meier survival curve of the effect of CCR5 expression on dataset analyzed for B. The cut-off used to determine low and high expression was the mean RNA expression of the whole sample by RSEM (CCL5=8.1, CCR5=5.8). (E) Correlation of CCL5 expression and CCR5 expression in esophageal cancers. (F) Multivariable analysis on the association between CCL5 expression, CCR5 expression, tumor grade and tumor type (ESCC vs. EAC) on esophageal cancer patient survival. RSEM = RNA-Seq by Expectation Maximization.