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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Gastroenterology. 2023 Apr 14;165(1):173–186. doi: 10.1053/j.gastro.2023.03.236

Figure 4. Acute (AP, CAP) and chronic (CP) pancreatitis states have distinct but common and increasingly active inflammatory pathway signatures.

Figure 4.

A. Comparison analysis from the IPA highlights a progressive increase in inflammatory responses, including macrophage classical activation signaling in canonical pathways and TNF and IL-1β in upstream analysis, throughout the pancreatitis progression from acute to chronic disease. B. Heatmap of differentially expressed immune markers associated with macrophage classical activation signaling in each disease state compared with controls (left). Dot plot depicting protein levels of serum immune markers associated with macrophage classical activation signaling (right). Estimated mean differences of NPX values in each comparison and FDR-adjusted p-values were used for the IPA.