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. Author manuscript; available in PMC: 2024 Jun 23.
Published in final edited form as: Circ Res. 2023 May 8;133(1):e1–e16. doi: 10.1161/CIRCRESAHA.122.322213

Figure 2. CM-specific FKBP5-deficiency enhances AF susceptibility.

Figure 2.

(A) Representative simultaneous recordings of surface ECG and intracardiac electrograms in Ctl and cKD mice, suggestive of sinus rhythm in Ctl and AF in cKD mice after pacing. (B) The incidence and (C) the duration of pacing-induced AF in Ctl and cKD mice. (D) Representative M-mode echocardiography recording in Ctl and cKD mice. (E-G) The quantification of LVEF%, ESD, and EDD in Ctl and cKD mice. (H) Representative long-axis echocardiography recording to assess left atria (LA) in Ctl and cKD mice. (I) The quantification of LA area. (J) Representative Picrosirius Red staining in whole hearts (i), atria (ii) and ventricles (iii) of Ctl and cKD mice. (K) The quantification of fibrosis areas in atria and ventricles of Ctl and cKD mice. p-values were determined with Fisher’s exact test in B, Mann-Whitney test in C and E, and unpaired Student’s t-test in F.