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. Author manuscript; available in PMC: 2024 Jun 23.
Published in final edited form as: Circ Res. 2023 May 8;133(1):e1–e16. doi: 10.1161/CIRCRESAHA.122.322213

Figure 3. CM-specific FKBP5-deficiency promotes arrhythmogenic alternans.

Figure 3.

(A) Representative activation maps in Ctl and cKD mice. (B) Quantification of APD and (C) AERP at 10 Hz pacing. (D) CV at 10 Hz and 15 Hz pacing. (E) Coefficient of variation (CoV) of CV at 10 Hz and 15 Hz pacing. (F) Representative examples of AP alternans in cKD mice evoked by 15 Hz pacing, but not by 10 Hz pacing. (G) Incidence of AP alternans. (H) Representative traces of normal rhythm in Ctl and atrial tachycardia in cKD mice after pacing. (I) Incidence of pacing-induced atrial arrhythmia ex vivo. p-values were determined with unpaired Student’s t-test in D (with Welch’s correction) and E, and Fisher’s exact test in G and I.