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. Author manuscript; available in PMC: 2024 Jun 23.
Published in final edited form as: Circ Res. 2023 May 8;133(1):e1–e16. doi: 10.1161/CIRCRESAHA.122.322213

Figure 5. CM-specific FKBP5-deficiency enhances the HIF-1α-mediated transcription of Slc8a1.

Figure 5.

(A-B) Increased SLC8A1 mRNA level in atrial tissue of cAF patients (A) and cKD mice (B). (C) Schematic diagram showed the 6 HREs in the promoter region (P1-P6) of cardiac Slc8a1. (D) ChIP-qPCR showed that the interaction between HIF-1α and the P5- and P6-regions of Slc8a1-promoter were increased in cKD tissue, which was further exacerbated under hypoxia. (E) EMSA results confirmed the direct binding between HIF-1α protein and the P6-probe. p-values were determined with Mann-Whitney test in A and B, and two-way ANOVA with Tukey’s comparison in D.