Skip to main content
. Author manuscript; available in PMC: 2024 Jun 23.
Published in final edited form as: Circ Res. 2023 May 8;133(1):e1–e16. doi: 10.1161/CIRCRESAHA.122.322213

Figure 7. HIF-1α inhibition prevents AF inducibility in FKBP5 cKD mice.

Figure 7.

(A) Timeline of HIF-1α inhibition studies in cKD mice. (B-C) Representative long-axis echocardiography images (B) and quantification (C) of left atrial (LA) area in cKD mice treated with vehicle (control) or 17-AAG. (D-F) Representative M-mode echocardiography images (D) and quantification of LVEF% (E) and diameters (F) of left ventricles in cKD mice treated with vehicle (control) or 17-AAG. (G-H) Representative Western blots (G) and quantification (H) of protein levels of NCX1, HIF-1α and HSP90 in atria of cKD mice treated with vehicle (control) or 17-AAG. (I-K) Representative recordings of surface and intracardiac electrograms (I) and the incidence (J) and duration (K) of pacing-induced AF in cKD mice treated with vehicle (control) or 17-AAG. p-values were determined with Mann-Whitney test in H and K, and Fisher’s exact test in J.