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NAC concentrations in dose escalation cohort
| Cohort | Trough [NAC], mM | Peak [NAC], mM | Achieved Target Concentration* | Delayed [NAC], mM | |||
|---|---|---|---|---|---|---|---|
| Median | Range | Median | Range | Frequency | Median | Range | |
| Observation | NA | NA | 0 | 0 - 0 | 0/16 | 0 | 0 - 0 |
| DL1 (225mg/kg) | 0 | 0 - 0 | 0.67 | 0.24 – 0.70 | 0/3 | 0 | 0 - 0 |
| DL2 (300mg/kg) | 0 | 0 - 0 | 1.95 | 0.36 – 3.67 | 4/6 | 0 | 0 – 15 |
| DL3 (450mg/kg) | 0 | 0 - 0 | 3.71 | 1.47 – 8.91 | 5/6 | 0.25 | 0 – 0.68 |
Peak serum [NAC] >1.5mM within 15 minutes following infusion; see Methods.
