Table 2.

Age and gender-adjusted odds of POAG diagnosis per decile of GRS among individuals in the NEIGHBORHOOD consortium.

A. TXNRD2 GRS				B. ME3 GRS				C. TXNRD2 + ME3 GRS
GRS Decile	Odds Ratio	95% CI	p-value	GRS Decile	Odds Ratio	95% CI	p-value	GRS Decile	Odds Ratio	95% CI	p-value
1	-	-	-	1	-	-	-	1	-	-	-
2	0.83	0.65, 1.07	0.15	2	0.98	0.76, 1.25	0.86	2	1.17	0.91, 1.51	0.21
3	1.09	0.85, 1.40	0.5	3	1.14	0.89, 1.45	0.3	3	1.31	1.02, 1.69	0.03
4	1.12	0.88, 1.44	0.36	4	1.1	0.86, 1.41	0.43	4	1.29	1.00, 1.66	0.047
5	1.1	0.86, 1.42	0.43	5	1.33	1.01, 1.75	0.04	5	1.05	0.82, 1.35	0.68
6	1.25	0.97, 1.60	0.08	6	1.37	1.07, 1.77	0.01	6	1.37	1.07, 1.77	0.01
7	1.06	0.83, 1.36	0.66	7	1.22	0.95, 1.55	0.12	7	1.31	1.02, 1.68	0.04
8	1.41	1.10, 1.81	0.007	8	1.27	0.99, 1.62	0.06	8	1.67	1.30, 2.14	<0.001
9	1.41	1.10, 1.81	0.007	9	1.39	1.08, 1.80	0.01	9	1.77	1.38, 2.28	<0.001
10	1.39	1.08, 1.78	0.01	10	1.25	0.94, 1.67	0.13	10	1.79	1.39, 2.30	<0.001

POAG= primary open-angle glaucoma; GRS= genetic risk score; CI= confidence interval