Table 3.
Summary of GRS results for specific glaucoma phenotypes among POAG cases in the NEIGHBORHOOD consortium.
| A. Maximal treated intraocular pressure (in mmHg) | |||||
|---|---|---|---|---|---|
| GRS | GRS Percentile | Mean (SD) Top GRS Percentile | Mean (SD) Bottom GRS Percentile | p-value | Adjusted p-value1 |
| TXNRD2 | 1% | 19.9 (7.1) (n=24) | 15.6 (3.9) (n=24) | 0.01 | 0.03 |
| 5% | 17.1 (5.6) (n=118) | 17.0 (4.8) (n=120) | 0.93 | 0.94 | |
| 10% | 17.3 (5.6) (n=241) | 17.8 (5.1) (n=235) | 0.28 | 0.84 | |
| ME3 | 1% | 19.2 (4.5) (n=24) | 17.9 (5.0) (n=24) | 0.36 | 0.43 |
| 5% | 18.2 (5.4) (n=118) | 18.3 (5.9) (n=118) | 0.94 | 0.94 | |
| 10% | 18.4 (5.6) (n=230) | 18.1 (5.9) (n=243) | 0.70 | 0.92 | |
| TXNRD2 + ME3 | 1% | 18.5 (5.1) (n=23) | 16.8 (5.8) (n=26) | 0.28 | 0.42 |
| 5% | 18.1 (5.6) (n=117) | 18.0 (5.5) (n=121) | 0.88 | 0.94 | |
| 10% | 17.8 (5.4) (n=230) | 18.0 (5.3) (n=239) | 0.77 | 0.92 | |
| B. Paracentral visual field loss | |||||
| GRS | GRS Percentile | Prevalence Top GRS Percentile | Prevalence Bottom GRS Percentile | p-value | Adjusted p-value1 |
| TXNRD2 | 1% | 18.2% (n=11) | 20.0% (n=5) | 0.93 | 0.93 |
| 5% | 42.6% (n=47) | 36.6% (n=41) | 0.57 | 0.62 | |
| 10% | 43.2% (n=95) | 42.9% (n=77) | 0.97 | 0.97 | |
| ME3 | 1% | 72.7% (n=11) | 14.3% (n=7) | 0.02 | 0.03 |
| 5% | 51.4% (n=37) | 44.4% (n=54) | 0.52 | 0.62 | |
| 10% | 52.5% (n=80) | 43.3% (n=90) | 0.23 | 0.69 | |
| TXNRD2 + ME3 | 1% | 88.9% (n=9) | 33.3% (n=12) | 0.01 | 0.03 |
| 5% | 41.3% (n=46) | 46.5% (n=43) | 0.62 | 0.62 | |
| 10% | 46.6% (n=88) | 41.9% (n=93) | 0.53 | 0.80 | |
1
Adjustment for multiple comparisons was performed using the False Discovery Rate (FDR) method
POAG= primary open-angle glaucoma; GRS= genetic risk score; mmHg= millimeters of mercury; SD= standard deviation