Table 2.
Cohort Characteristics of Study Population Stratified by Presence of Clonal Hematopoiesis of Indeterminate Potential (CHIP)
| Characteristic | CHIP+ | CHIP− | p-value |
|---|---|---|---|
| (n=24) | (n=854) | ||
| Age at blood draw (median, range) | 38 [25, 42] | 39 [22,42] | 0.133 |
| Smoking Status (baseline) | 0.337* | ||
| Never | 11 (46%) | 502 (59%) | |
| Current/Former | 9 (38%) | 249 (29%) | |
| Unknown | 4 (17%) | 103 (12%) | |
| Cancer Stage | 0.257 | ||
| 0 | 0 (0%) | 55 (6%) | |
| I | 10 (42%) | 259 (30%) | |
| II | 11 (46%) | 350 (41%) | |
| III | 1 (4%) | 144 (17%) | |
| IV | 2 (8%) | 46 (5%) | |
| Surgery | 0.759 | ||
| Yes | 22 (92%) | 741 (87%) | |
| Unknown | 2 (8%) | 114 (13%) | |
| Radiation | 0.838 | ||
| Yes | 11 (46%) | 416 (49%) | |
| No | 13 (54%) | 438 (51%) | |
| Chemotherapy | >0.999 | ||
| Yes | 19 (79%) | 655 (77%) | |
| No | 5 (21%) | 199 (23%) | |
| Hormone Therapy (within 1 year of diagnosis) | 0.802* | ||
| Yes | 13 (54%) | 480 (56%) | |
| No | 5 (21%) | 230 (27%) | |
| Unknown | 6 (25%) | 144 (17%) |
*
p-value estimated excluding the unknown group
Age was tested using a Wilcoxon Rank-Sum test, all other variables were tested with a Fisher’s Exact test.