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. Author manuscript; available in PMC: 2024 Jun 27.
Published in final edited form as: Chemistry. 2023 May 8;29(36):e202300842. doi: 10.1002/chem.202300842

Scheme 1.

Scheme 1.

Diseases associated with aldehyde accumulation (A) and various strategies used for detoxification, including biological (B), stoichiometric (C), and catalytic (D) methods. ALDH = aldehyde dehydrogenase; AKR = aldo-keto reductase; GSH = glutathione; SIMCat = small-molecule intracellular metal catalyst.