Table 1.

Functions for the ubiquitous mammalian WASP-family proteins in cellular homeostasis and stress responses.

Proteostasis
Autophagy
Subcellular process	WASP-Family Member	References
Autophagosome biogenesis	WASH	Xia et al. (2013) Zavodszky et al. (2014)
	WHAMM	Kast et al. (2015) Mathiowetz et al. (2017)
	JMY	Coutts and La Thangue (2015)
Autophagosome rocketing	WHAMM	Kast et al. (2015)
	JMY	Hu and Mullins (2019)
Autolysosome regeneration	WASH	Monfregola et al. (2010) Ryder et al. (2013)
	WHAMM	Dai et al. (2019) Wu et al. (2021)
Mitochondrial homeostasis	WAVE complex(es)	Fung et al. (2022)
Endocytosis
Endocytic pit formation	N-WASP	Akamatsu et al. (2020) Jin et al. (2022) Serwas et al. (2022)
Cargo internalization	N-WASP	Benesch et al. (2005) Innocenti et al. (2005) Merrifield et al. (2004) Bu et al. (2010)
Endolysosomal Trafficking
Endocytic vesicle rocketing	N-WASP	Taunton et al. (2000) Benesch et al. (2002) Southwick et al. (2003)
Endosomal cargo sorting	WASH	Derivery et al. (2009) Gomez and Billadeau (2009) Duleh and Welch (2010) Zech et al. (2011) Park et al. (2013)
	N-WASP	Juin et al. (2019)
Lysosomal maintenance	WASH	Gomez et al. (2012) Courtland et al. (2021) Park et al. (2013)
Secretory Trafficking
Golgi-ER transport	N-WASP	Luna et al. (2002) Matas et al. (2004)
ER-Golgi transport	WHAMM	Campellone et al. (2008b) Russo et al. (2016)
trans-Golgi transport	JMY	Schlüter et al. (2014)
Apoptosis
Intrinsic Apoptosis
Pro-apoptotic transcription	JMY	Shikama et al. (1999) Demonacos et al. (2001) Coutts et al. (2009)
Pro-MOMP Bcl-2 functions	WAVE1	Danial et al. (2003) Cheng et al. (2007)
Anti-MOMP Bcl-2 functions	WAVE1	Kang et al. (2010)
Caspase activation	JMY	King et al. (2021) King and Campellone (2023)
	WHAMM	King et al. (2021) King and Campellone (2023)
Nuclear/Chromatin Biology
Gene Expression
Pol II-mediated transcription	N-WASP	Suetsugu and Takenawa (2003) Wu et al. (2006) Wei et al. (2020)
Pluripotent reprogramming	WAVE1	Miyamoto et al. (2011) Miyamoto et al. (2013)
Chromatin remodeling	WASH	Xia et al. (2014)
DNA Repair
dsDNA break relocalization	WASH/WAVE?	Caridi et al. (2018) Schrank et al. (2018)
dsDNA break repair	WASH	Wang et al. (2022)
Chromosome Partitioning
Spindle organization	JMY	Sun et al. (2011a) Liu et al. (2012)
	WAVE1	Sun et al. (2011c)
		Liu et al. (2012)
	WHAMM	Huang et al. (2013) Jo et al. (2021)
Centrosomal dynamics	WASH	Farina et al. (2016) Farina et al. (2019)