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. Author manuscript; available in PMC: 2024 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2023 Apr 5;92:43–79. doi: 10.1146/annurev-biochem-052521-013938

Figure 9.

Figure 9

Glycosylases and their design and applications in genomic DNA base editing. (Top) Glycosylases initiate the BER pathway by excising modified nucleobases in dsDNA or ssDNA. (Bottom) Representative base editor architecture is shown, with essential and non-essential components indicated with solid and dashed outlines, respectively. The conserved β-sheet core of uracil glycosylases is shown, with an emphasis on the locations of the active site residues and critical DNA-binding sites, as well as other signature motifs.