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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Exp Neurol. 2023 May 6;366:114433. doi: 10.1016/j.expneurol.2023.114433

Figure 5. FLNA and RPS6KA3: their proximity to telomeres and A+T content.

Figure 5.

(a) Chromosome number of ten (#71-80) genes associated with CH in mice, rats, and humans. Note that FLNA and RPS6KA3 are located on the X chromosome of all three species (b) The FL size of ten genes (#71-80) in mice, rats, and humans. Note that FLNA and TBC1D7 show consistent molecular sizes in three species while other genes differ in humans as compared to rodents (c) Proximity to telomeres in twenty genes (#61-80) including two X chromosome genes over three species. Note that more than a half of twenty human genes in this list ($61-80) have evolved in a way meeting proximity to telomeres or F(i) as 18 of 20 human genes have proximity to telomeres at <50 Mb as compared to those of mice and rats. Arrows in red, orange, blue, green, and purple indicate VANGL1, NRAS, NF1, FLNA, and RPS6KA3, respectively (upper plot). A + T content of twenty genes (#61-80) over three species demonstrate a limited number of 20 genes meeting the second factor, F(ii). Arrows in red, orange, blue, green, and purple indicate PIK3CA, NRAS, SNX10, FLNA, and RPS6KA3, respectively (lower plot). (d) Chromosome counts of frequently used laboratory animals (mice & rats) and humans as compared to other species such as Panda to yellow fever mosquito (Y.F. mosq). Including Panda (42), other species shown here have fewer number of chromosomes than humans at 46 chromosomes (23 pairs). (e) Chromosome counts of frequently used laboratory animals and humans as compared to other species such as Skunk to mule. Except mouse and rat, other species such as mule (72) shown here have more chromosomes than humans.