Table 2. Screening of selected peptidyl ligand sequences.
| |||
| entry | [Rh] | yielda (%) | erb |
|---|---|---|---|
| 1 | Rh2(Boc-Asp-D-Pro-Acpc-Leu-OMe)4 | 56 | 71:29 |
| 2 | Rh2(Boc-D-Asp-D-Pro-Acpc-Leu-OMe)4 | 30 | 53:47 |
| 3 | Rh2(Boc-Asp-Pro-Acpc-Leu-OMe)4 | 27 | 53:47 |
| 4 | Rh2(Boc-D-Asp-Pro-Acpc-Leu-OMe)4 | 35 | 48:52 |
| 5 | Rh2(Boc-Asp-D-Pro-Aib-Leu-OMe)4 | 50 | 56:44 |
| 6 | Rh2(Boc-Asp-D-Pro-Acpc-Ala-OMe)4 | 42 | 45:55 |
| 7 | Rh2(Boc-Asp-D-Pro-Acpc-Ile-OMe)4 | 73 | 79:21 |
| 8 | Rh2(Boc-Asp-D-Pro-Acpc-Chg-OMe)4 | 80 | 82:18 |
| 9 | Rh2(Boc-Asp-D-Pro-Acpc-Chg-NMe2)4 (C1) | 81 | 90:10 |
| 10 | Rh2(Boc-Asp-D-Pro-Acpc-Chg-Pyrr)4 (C2) | 73 | 90:10 |
| 11 | Rh2(Piv-Asp-D-Pro-Acpc-Chg-NMe2)4 | 31 | 50:50 |
| 12 | Rh2(MeOCO-Asp-D-Pro-Acpc-Chg-NMe2)4 | 28 | 54:64 |
| 13 | Rh2(Boc-Glu-D-Pro-Acpc-Leu-OMe)4 | 40 | 42:58 |
| |||
Determined by 1H NMR in CDCl3 using trimethyl 1,3,5-benzenetricarboxylate as internal standard.
Determined by chiral HPLC.