Cardiac extraction of glucose (A), fatty acid (B), lactate (C), and ketone (D). E. ATP levels in the LV tissue. Levels of mRNA encoding GLUT4 (glucose transporter 4, F), CD36 (G), CPT-1β (Carnitine palmitoyl transferase 1β, H), MCT1 (monocarboxylate transporter 1, I), and SCOT (succinyl CoA:3-oxo acid CoA transferase, J). Veh indicates vehicle and KE, ketone ester. *p < 0.05, **p < 0.01, ***p < 0.001.