Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 26;14:1212149. doi: 10.3389/fmicb.2023.1212149

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Lei, Hanks, Bao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The cytidine repeat of mga as a switch for M protein production and the role of the switch in the circulation among human hosts. (A) Slipped-strand mispairing of the polycytidine tract of mga functions as a switch for M protein production. The c.1574C[8] and c.1574C[6] repeats of mga lead to functional Mga, which turns on M protein expression whereas c.1574C[7] leads to nonfunctional Mga, which turns off M protein expression. (B) Proposed role of the switch of M protein production in GAS circulation among human hosts. It is proposed that humoral immunity in patients turns off the switch, resulting in M^- variants that are transmitted to naïve host where innate immunity turns on the switch to produce M protein.