TABLE 1.

Viral vector comparison in terms of their applicability to DMD gene therapy.

Characteristics	Adenovirus	Lentivirus	AAV
Genome	dsDNA	ssRNA	ssDNA
Capacity (kb)	Up to 30 kb	Up to 10 kb	Up to 4.7 kb
Genome integration	NO	Yes	On rare events
Expression duration	Transient	Persistent	Intermediate
Non-dividing cell transduction	Yes	Yes	Yes
Ability to target satellite cells	NO	Yes	NO
Immune response	High	Low	Very low
Risk	Elicits viral-induced inflammation/cytotoxicity	Insertional mutagenesis/potential for replication of competent virus	High safety profile