Figure 2. Arl13b^V358A/V358A mutant mice exhibit a progressive cystic kidney phenotype.

(A) H&E staining of kidney cross sections from 18-week-old male mice. Scale bar: 2000 μm. (B) Tubule dilations appeared in Arl13b^V358A/V358A kidneys around P10 and progressed to cysts by weaning age (P24). Scale bars in P10, P18, P24: 200 μm. Scale bar in P120: 1000 μm. (C) Cyst formation in Arl13b^V358A/V358A quantified by cystic index, mean ± SEM. n ≥ 7 mice per genotype and sex. Two-way ANOVA, ** p < 0.01. (D) Arl13b^V358A/V358A mice display normal renal physiology: Blood urea nitrogen (BUN) and serum creatinine levels were measured from 18-week old male and female mice, mean ± SEM. n ≥ 7 per genotype and sex. Two-way ANOVA, no significant change between Arl13b^V358A/V358A and control animals.