Table 5.

Responsiveness comparison of changes (T3 minus T2), mean difference (95% confidence interval)

A-HRSI subscale	PGIC				Participant-reported ECOG PS
	Change for the worse vs no change	p	Change for the worse vs change for the better	p	Change for the worse vs no change	p	Change for the worse vs change for the better	p
Physical symptoms	0.22 (− 0.30 to 0.73)	0.40	0.39 (− 0.13 to 0.90)	0.14	0.43 (0.05–0.82)	0.03	0.60 (0.13–1.07)	0.01
Impact on physical functioning	0.71 (− 0.01 to 1.43)	0.06	0.65 (− 0.08 to 1.38)	0.08	0.53 (0.02–1.03)	0.04	1.39 (0.77–2.01)	0.01
Impact on psychological functioning	0.86 (− 0.02 to 1.73)	0.06	1.12 (0.23–2.01)	0.01	0.72 (0.04–1.40)	0.04	0.98 (0.14–1.82)	0.02

A-HRSI indicates ANCHOR Health-Related Symptom Index; Participant-Reported ECOG PS, Participant-Reported Eastern Cooperative Oncology Group Performance Status; PGIC, Participant Global Impression of Change