Figure 3: CD4+ T helper cell subsets.
CD4+ T helper cells can be identified by various cell surface markers and chemokine receptors. (A) Tregs have a CD25hiCD127low phenotype, and (B) T follicular helper cells (CXCR5+CD45RA−; Tfh), (C) Th1 cells (CXCR3+CCR6−), and Th17 (CXCR3−CCR6+) can be identified via expression of the chemokine receptors CXCR5, CXCR3 and CCR6, respectively.