Conditions for the synthesis of olanzapine derivatives in the reaction of DOLA (1 eq.) : CH₃I (1.5 eq.) : K₂CO₃ or DIPEA (3 eq.) : catalyst (0.01 eq.) in the presence of microwave irradiation (MW) and ultrasound (“)))”).

No.	Conditions	Temp.a [°C]	Pressureb [bar]	Solvent/base/catalyst	Reaction time [min]	Yield [%]
1	MW	147	2.3	DMF/K2CO3/TBAB	2	57
2	MW	150	4.7	DMF/K2CO3/TBAB	1.5	69
3	MW	105	Atm	DMF/K2CO3/TBAB	1.5	48
4	MW	150	3.2	DMF//K2CO3/DABCO	1	71
5	MW	150	1.9	DMF/K2CO3/BTBAC	1	69
6	MW	150	2.6	DMF/K2CO3/TEAC	1	73
7	MW	150	2.3	DMF/K2CO3/TMAB	1	72
8	MW	150	2.2	DMF/K2CO3/TEBA	1	87
9	MW	150	2.5	DMF/K2CO3/CTAB	1	95
10	MW	150	0.5	DMF/K2CO3/-	1	38
11	MW	150	0.5	NaDES/K2CO3/TBAB	2	46
12	MW	150	0.5	NaDES/K2CO3/-	2	37
13	MW	150	2.5	NaDES/Glycerine/K2CO3/TBAB	2.5	53
14	)))	45	Atm	DMF/K2CO3/TBAB	120	40
15	)))	45	Atm	DMF/K2CO3/DABCO	120	45
16	)))	45	Atm	DMF/K2CO3/-	120	15
17	)))	45	Atm	NaDES/K2CO3/TBAB	120	25
18	)))	45	Atm	NaDES/DIPEA/TBAB	120	61

^aHighest observed data entered, the maximum temperature was set to 150 °C; reactions in the presence of ultrasound were carried out under reflux, due to the boiling point of CH₃I (43 °C).

^bHighest observed data entered, the maximum pressure was set to 10 bar.