. 2023 Jul 10;13(30):20467–20476. doi: 10.1039/d3ra03926a

Toxicity of olanzapine derivatives towards MCF7 and MDA-MB-231 breast cancer cell lines. Half-maximal inhibitory concentrations (IC₅₀) and maximal inhibition levels were calculated by fitting the normalized experimental values to three-parameter sigmoidal curve equation^a.

Entry	Compound	MCF7		MDA-MB-231
Entry	Compound	IC₅₀	Maximal inhibition	IC₅₀	Maximal inhibition
1	Olanzapine	n/d	n/d	n/d	n/d
2	DOLA	10.0 μM	13.8%	38.1 μM	10.8%
3	5	28.6 μM	27.1%	4.0 μM	40.3%
4	6	n/d	n/d	26.4 μM	53.1%
5	7	18.8 μM	50.1%	3.5 μM	51.0%
6	8	13.7 μM	40.4%	29.7 μM	99.9%

n/a, not determined due to lack of significant inhibition of cell viability.

Toxicity of olanzapine derivatives towards MCF7 and MDA-MB-231 breast cancer cell lines. Half-maximal inhibitory concentrations (IC50) and maximal inhibition levels were calculated by fitting the normalized experimental values to three-parameter sigmoidal curve equationa.