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. 2023 Jun 26;14:1191357. doi: 10.3389/fimmu.2023.1191357

Figure 2.

Figure 2

Characterization of gene expression differences in CD4+ and CD8+T cells across three conditions. (A) UMAP plots of mean gene expression from Th1 (Top) and Th17 (Bottom) gene signatures, split by condition. (B) Box plots showing the IFNG expression in CD4_Th1-01, CD4_Th1-02 and CD8_Pro subset per condition. (C) Box plots showing the cytotoxicity scores in effector T cells across different conditions. (D) UMAP plots of exhaustion response scores and exhaustion scores in activated T cells, split by condition. (E) Box plots showing XAF1 and IRF1 expression in T cells across each condition. (F) Dot plots showing the expression of selected apoptosis-associated genes in T cells across each condition. (G) Box plots of leukocyte migration scores in T cells across different conditions. Student’s T-test was applied to test significance in (B,C, E, G) *p<0.05, ****p<0.0001.