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. 2023 Jun 26;14:1191357. doi: 10.3389/fimmu.2023.1191357

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Copyright © 2023 Yang, Yan, Xue, Sun, Zhang, Guo, Wang, Li, Liang, Wu, Wang, Liao, Long, Zheng, Wei, Zhang, Liu, Che, Luu, Pan, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of gene expression differences in NK cells across three conditions. (A) Dot plots showing the expression of selected genes in each NK cell subtype per condition. (B) PAGA analysis of NK cell pseudo-time: the associated cell type is shown. (C) Box plots of the expression of IFNG, TNF and cytotoxicity scores in NK cells per condition. (D) Heatmap plots of the expression of selected exhaustion associated genes in NK_memory, NK_CD56 and NK_CD160 cells per condition. (E) Box plots showing the apoptotic scores in NK cells and subtypes per condition. (F) Heatmap plots of HLA-II molecules in NK cells per condition. (G) Heatmap plots of HLA-I molecules in NK cells per condition. Student’s T-test was applied to test significance in (A-E). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ^nsp>0.05.