VEGFR-2 enzymatic target of compounds 3a, 3i and 3la.
| Sample | IC50 nM ± SD |
|---|---|
| 3a | 38.28 ± 1.79 |
| 3i | 8.93 ± 0.61 |
| 3l | 119 ± 4.1 |
| Sorafenib | 30 ± 1.39 |
“Values are expressed as the average of three independent replicates”. “IC50 values were calculated via the sigmoidal non-linear regression curve fitting of the percentage inhibition against the concentration of the compound”.