Table 4.
Factors associated with progression to PSCR and no SCR at end of follow-up
| Progression to PSCR (analysis on n = 109) |
No SCR at end of follow-up (analysis on n = 126) |
|||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | P value | Unadjusted OR (95% CI) | P value∗ | |
| Gender | ||||
| Male | Reference | Reference | ||
| Female | 0.404 (0.126-1.297) | .128 | 2.485 (1.210-5.101) | .013 |
| Hb genotype | ||||
| HbSS/HbSβ0/HbSβ+ | Reference | 3.726 (1.699-8.169) | ||
| HbSC | 5.973 (1.812-19.684) | .003 | Reference | .001 |
| Age | ||||
| y | 0.988 (95% CI, 0.934-1.045) | .671 | 0.977 (95% CI, 0.946-1.009) | .161 |
| HbF | ||||
| % | 0.812 (0.663-0.993) | .043 | 1.201 (1.093-1.319) | .001 |
| Hb level | ||||
| mmol/L | 1.565 (0.883-2.774) | .125 | 0.673 (0.479-0.946) | .022 |
| Lactate dehydrogenase | ||||
| U/L | 0.997 (0.993-1.000) | .086 | 1.001 (0.999-1.003) | .232 |
| Bilirubin | ||||
| μmol/L | 1.001 (0.987-1.016) | .856 | 1.003 (0.993-1.013) | .601 |
| Reticulocytes | ||||
| % | 0.996 (0.882-1.124) | .944 | 1.019 (0.943-1.100) | .640 |
∗
Significant P-values (P < 0.05) are shown in bold.