Table 1.
Design parameters and response's constraints of 23 full factorial design of DUL-loaded elastosomes.
| Independent Variables | Level of Variables |
|
|---|---|---|
| (−1) | (+1) | |
| X1: Span®60: CH ratio | 1:1 | 5:1 |
| X2: EA Type | Brij S2 | Cremophor RH 40 |
| X3: EA Amount (mg) | 5 | 10 |
| Response's Constraints | ||
| Y1: E.E. ⁎ (%) | Maximize | |
| Y2: PS (nm) | Minimize | |
| Y3: ZP (mV) | Maximize (as absolute values) | |
| Y4: Q0.5h (%) | Maximize | |
| Y5: Q8h (%) | Maximize | |