Table 3.
Experimental runs, independent variables (formulation factors) and dependent variables (measured responses) of 23 full factorial design of the developed DUL-loaded elastosomes.
| Formulae | Formulation Factors (Independent Variables) |
Measured Responses (Dependent Variables) |
||||||
|---|---|---|---|---|---|---|---|---|
| X1: Span®60: CH ratio | X2: EA Type | X3: EA Amount (mg) | Y1: E.E. |
Y2: PS |
Y3: ZP |
Y4: Q0.5h |
Y5: Q8h |
|
| (%) | (nm) | (mV) | (%) | (%) | ||||
| DUL-E1 | 1:1 | Brij S2 | 5 | 81.5 ± 3.2 | 432 ± 13.2 | −30.8 ± 3.3 | 15.6 ± 0.9 | 79.3 ± 3.8 |
| DUL-E2 | 1:1 | Brij S2 | 10 | 78.9 ± 2.1 | 398 ± 9.1 | −37.3 ± 4.5 | 18.1 ± 2.8 | 85.8 ± 1.7 |
| DUL-E3 | 1:1 | Cremophor RH 40 | 5 | 77.2 ± 2.9 | 385 ± 21.5 | −18.5 ± 1.4 | 22.9 ± 1.4 | 83.2 ± 1.7 |
| DUL-E4 | 1:1 | Cremophor RH 40 | 10 | 70.3 ± 4.1 | 353 ± 11.2 | −22.7 ± 3.6 | 26.2 ± 1.5 | 88.7 ± 2 |
| DUL-E5 | 5:1 | Brij S2 | 5 | 88.9 ± 1.8 | 751 ± 17.3 | −32.2 ± 2.2 | 10.4 ± 1.8 | 66.4 ± 0.8 |
| DUL-E6 | 5:1 | Brij S2 | 10 | 82.6 ± 2.2 | 693 ± 8 | −39.4 ± 5.3 | 14.5 ± 0.9 | 72.1 ± 3.1 |
| DUL-E7 | 5:1 | Cremophor RH 40 | 5 | 80.4 ± 1.3 | 708 ± 16.2 | −24.6 ± 2 | 16.3 ± 2.9 | 71.5 ± 1.9 |
| DUL-E8 | 5:1 | Cremophor RH 40 | 10 | 74.8 ± 3.7 | 661 ± 15.5 | −28.4 ± 3.3 | 20.1 ± 1.4 | 75.3 ± 1.3 |
| DUL-bilosomes | 1:1 | – | – | 83.5 ± 3.5 | 365 ± 21.5 | −30.2 ± 2.2 | 14.1 ± 2.8 | 76.2 ± 2.2 |