Table 5.
CD4+ polypositive T cells after stimulation with GI.4 and GII.4 VLPs expressed as Geometric Mean of the cell count at scheduled time points for each study group.
| Time point | ||||||
|---|---|---|---|---|---|---|
| CD4+ polypositive | Study group | Parameter 95% CI |
Day 1 | Day 29 | Day 57 | Day 365 |
| GI.4 Chiba 407 (1987) | rNV-2v 50 µg | Geomean* | 22.2 | 337.9 | 457.6 | 114.9 |
| 95% CI | 7.5 - 65.8 | 158.6 - 719.9 | 305.7 - 685.0 | 50.8 - 260.3 | ||
| rNV-2v 150 µg | Geomean | 13.8 | 314.4 | 378.6 | 170.6 | |
| 95% CI | 4.4 - 43.3 | 247.8 - 399.1 | 286.5 - 500.3 | 87.9 - 331.0 | ||
| Placebo | Geomean | 17.6 | 21.9 | 32.6 | 10.2 | |
| 95% CI | 5.6 - 55.9 | 7.8 - 61.8 | 13.1 - 81.1 | 3.3 - 32.0 | ||
| GII.4 Aomori 2 (2006) | rNV-2v 50 µg | Geomean | 56.6 | 585.3 | 459 | 133.2 |
| 95% CI | 20.0 - 160.8 | 428.4 - 799.8 | 273.9 - 769.3 | 60.4 - 293.9 | ||
| rNV-2v 150 µg | Geomean | 96.8 | 515.5 | 581.3 | 210.8 | |
| 95% CI | 42.7 - 219.2 | 379.3 - 700.5 | 437.4 - 772.5 | 96.9 - 458.5 | ||
| Placebo | Geomean | 50 | 42.8 | 36.9 | 27.7 | |
| 95% CI | 18.2 - 137.2 | 16.5 - 110.8 | 13.0 - 105.0 | 10.3 - 74.6 | ||
CI, confidence interval; Geomean, geometric mean of the cell count.
*Geometric mean values are expressed as cell count (frequencies per million parent cells.