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. 2023 Jun 5;15(7):e17230. doi: 10.15252/emmm.202217230

Figure EV2. Injection of rAAV serotype 2/8 can also lead to liver injury and necroptosis in db/db mice.

Figure EV2

  • A, B
    Schematic of rAAV serotype 2/8 (rAAV2/8) package (A) and the experimental design for the effect of rAAV2/8 injection on liver function and hepatic necroptosis (B). ITR, AAV2 ITR.
  • C–F
    Two months after a single injection of rAAV2/8, db/db mice showed similar blood glucose levels (D), and increased body weight (C), serum ALT (E) and AST (F) activities compared with those before injection of rAAV2/8. n = 5.
  • G
    Liver images, H&E staining of liver sections and the incidence of hepatic necroptosis (Ncp) for mice in (C). NML, Normal.

Data information: In (C–F), data are presented as mean ± SD. Student's t‐test.