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. 2023 Jun 5;15(7):e17230. doi: 10.15252/emmm.202217230

Figure EV4. Effect of rAAV injection on hepatic glycogen content and apoptosis in hyperglycemic mice and on endogenous Pebp1 level in liver of hyperglycemic and obese mice.

Figure EV4

  1. Two months after a single injection of rAAV, hyperglycemic mice induced by streptozotocin showed similar glycogen content compared with those mice injected with PBS. n = 9–10.
  2. The hepatic protein levels of cleaved Caspase 3 (cl‐Casp3) and cleaved Caspase 8 (cl‐Casp8) in the livers of mice in (A) were measured to monitor apoptosis. n = 9–10.
  3. The hepatic mRNA level of Pebp1 were similar in the high ALT & AST subgroup and low ALT & AST subgroup from HFD‐induced hyperglycemic and obese mice injected with rAAV‐si‐NC as shown in Fig 6D and E. n = 5 biological replicates.
  4. The hepatic protein level of Pebp1 from mice in (C).

Data information: In (A–D), data are presented as mean ± SD. Student's t‐test.