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. 2023 Jun 5;15(7):e17230. doi: 10.15252/emmm.202217230

Figure EV5. Suppression of PEBP1 signaling alleviates inflammation and necroptosis in human macrophages.

Figure EV5

  • A
    The effect of si‐PEBP1 and si‐TBK1 in THP‐1 human macrophages. n = 6 biological replicates.
  • B
    Knockdown of PEBP1 and TBK1 markedly blocked the increase of some key inflammatory factors in THP‐1 macrophages treated with poly(I:C). n = 9 biological replicates.
  • C–E
    Knockdown of PEBP1 and TBK1 markedly blocked the loss of cell membrane integrity (C‐D, n = 3 in triplicate) and the increase of p‐MLKL level (E, n = 8 biological replicates) of THP‐1 macrophages induced by poly(I:C) and z‐VAD‐fmk.

Data information: In (A, B, D, E), data are presented as mean ± SD. Student's t‐test.