Table 1.
The Keap1-Nrf2 binding affinity of the unsymmetric bisulfonamides determined by the fluorescence anisotropy assay..
Entry | R | KD (nM)a | Entry | R | KD (nM) |
---|---|---|---|---|---|
A1 | ![]() |
>10000 | A7 | ![]() |
1433 |
A2 | ![]() |
1304 | A8 | ![]() |
1153 |
A3 | ![]() |
>10000 | A9 | ![]() |
1143 |
A4 | ![]() |
1109 | A10 | ![]() |
3270 |
A5 | ![]() |
>10000 | A11 | ![]() |
1275 |
A6 | ![]() |
2066 | A12 | ![]() |
>10000 |
POZL | ![]() |
940 | A13 | ![]() |
>10000 |
NXPZ-2 | ![]() |
230 |
Duplicated experiment and the average data.