Table 2.
Reports with MRI data from patients with HSV encephalitis.
| GCS (median and range) or level of consciousness on admission | Seizures/status epilepticus | Mechanical ventilation | Patients from study with MRI | Time from admission to MRI in Median† days (IQR) | Abnormal MRI | FLAIR/T2 abnormalities | DWI | Bilateral | >3 lobes involved | |
|---|---|---|---|---|---|---|---|---|---|---|
| Sili et al. (32) | Somnolence, stupor or coma in 35% | 55% | n.a. | 106/106* | n.a. | 95% | n.a. | n.a. | 20% | “Extensive” 17% |
| Kalita et al. (39) | <13 in 93% <8 in 60% |
83%/48% | n.a. | 40/40 | n.a. | n.a. | n.a. | n.a. | 78% | n.a. |
| Kim et al. (40) | Mean 13 (range 5–15) | 55% | n.a. | 25/29 | Mean 2.8 (range 0–7) | n.a. | 64% | 59% | 27% | |
| Jordan et al. (55) | Somnolence, sopor, coma in 73% | 67% | 20% | 15/15 | Within 48 h | 87% | 80% | 90% | 53% | |
| Singh et al. (41) | 14 (10–15) | 47%/13% | 36% | 40/45 | 2 (1–8.5) | 95% | 50% | 42% | ||
| Bewersdorf et al. (44) | n.a. | 22% | n.a. | 18/18 | Mean 5.5 (range 1–16) | 94% | 94% | 65% | 41% | |
| Jaquet et al. (47) | 9 (6–12) | 36%/10% | 62% | 225/259 | 3 (1–9) | 98% | 62% | 33% | ||
| Sarton et al. (48) | 9 (6–12) | 70%/46% | 69% | 138/138 | 3 (1–8) | 99% | 98% | 48% | 36% | 38% |
| Mulatero et al. (52) | n.a. | 21%/11% | 34% | 76/76 | Mean 5.8 (±8.2) | n.a. | n.a. | n.a. | n.a. | n.a. |
n.a, data not available; *of the 106 patients included; 55 had positive CSF HSV PCR, 25 had negative CSF HSV PCR and 26 were not tested for CSF HSV by PCR; †Median, if not otherwise indicated.