TABLE 2.

Animal weights, blood pressure, serum and urine parameters.

Weights, blood pressure, plasma and urine parameters	Sham	2K1C + placebo	2K1C + ICA
Body weight [g]	388.6 ± 11.2	292.4 ± 11.7*	284.9 ± 10.8*
Rel. right kidney weight [mg/g]	3.15 ± 0.07	5.56 ± 0.33*	5.30 ± 0.25*
Rel. left kidney weight [mg/g]	3.11 ± 0.08	3.82 ± 0.16*	4.02 ± 0.21*
Rel. left ventricular weight [mg/g]	2.20 ± 0.04	3.92 ± 0.15*	3.91 ± 0.11*
MAP intra-arterial [mm Hg]	128.3 ± 9.2	221.1 ± 6.4*	212.3 ± 7.7*
BP tail cuff [mm Hg]	95.6 ± 5.5	208.3 ± 6.7*	196.7 ± 8.9*
Serum aldosterone [ng/ml]	441.0 ± 64.7	3,133.4 ± 561.4*	2943.6 ± 465.6*
Serum creatinine [mg/dl]	0.20 ± 0.03	0.26 ± 0.03	0.48 ± 0.14*
Serum urea [mg/dl]	30.16 ± 3.39	60.05 ± 6.34	100.45 ± 19.55 * §
Albuminuria [mg/g creatinine]	0.046 ± 0.002	12.51 ± 2.91*	12.06 ± 3.61*

*, p < 0.05 versus sham; §, p < 0.05 versus 2K1C + placebo (ANOVA, followed by Fisher’s Least Significant Differences post-hoc test); N = 8–9, sham; n = 15–18, 2K1C + placebo; n = 12–15, 2K1C + ICA., sham, control sham operation; 2K1C, 2-kidney-1-clip hypertensive rats; ICA, 2-(1-chloro-4- hydroxyisoquinoline- 3-carboxamido) acetate; MAP, mean arterial blood pressure; BP, blood pressure.