TABLE 3.
Markers of organ damage.
| Sham | 2K1C + placebo | 2K1C + ICA | |
|---|---|---|---|
| Right Kidney: | |||
| Glomerulosclerosis [score] | 0.66 ± 0.08 | 1.65 ± 0.09* | 1.61 ± 0.14* |
| Interst. collagen IV [% pos. stain] | 4.44 ± 0.52 | 10.87 ± 1.26* | 11.67 ± 1.30* |
| Interst. Macrophages [no/view] | 3.19 ± 0.36 | 10.33 ± 1.18* | 10.06 ± 0.86* |
| KIM-1 expression [rel. units] | 1.00 ± 0.19 | 237.37 ± 38.13* | 411.63 ± 107.57* |
| Ngal expression [rel. units] | 1.00 ± 0.12 | 22.27 ± 6.15* | 20.30 ± 3.89* |
| Endothelin-1 expr. [rel. units] | 1.00 ± 0.07 | 4.14 ± 0.41* | 4.72 ± 0.76* |
| Adrenomedullin expr. [rel. units] | 1.00 ± 0.04 | 1.29 ± 0.10 | 1.27 ± 0.13 |
| PAI-1 expression [rel. units] | 1.00 ± 0.13 | 5.49 ± 1.11* | 5.73 ± 0.91* |
| iNOS expression [rel. units] | 1.00 ± 0.13 | 2.99 ± 0.76 | 4.01 ± 0.82* |
| eNOS expression [rel. units] | 1.00 ± 0.06 | 1.32 ± 0.07* | 1.17 ± 0.10 |
| Left Kidney: | |||
| KIM-1 expression [rel. units] | 1.00 ± 0.22 | 243.27 ± 91.77 | 1,134.85 ± 521.65* § |
| IL-11 expression [rel. units] | 1.00 ± 0.12 | 2.51 ± 0.30 | 4.20 ± 0.85* § |
| Endothelin-1 expr. [rel. units] | 1.00 ± 0.08 | 2.10 ± 0.30 | 3.27 ± 0.63* |
| iNOS expression [rel. units] | 1.00 ± 0.12 | 1.43 ± 0.34 | 3.85 ± 1.13* § |
| Left ventricle: | |||
| PAI-1 expression [rel. units] | 1.00 ± 0.13 | 1.69 ± 0.22 | 2.90 ± 0.24* § |
*, p<0.05 versus sham; §, p < 0.05 versus 2K1C + placebo (ANOVA, followed by Fisher’s Least Significant Differences post-hoc test); N = 8-9, sham; n = 15-18, 2K1C + placebo; n = 12-15, 2K1C + ICA., sham, control sham operation; 2K1C, 2-kidney-1-clip hypertensive rats; ICA, 2-(1-chloro-4- hydroxyisoquinoline- 3-carboxamido) acetate.