Tab. 2: Immunosuppressive toxicity signatures.
The toxicity signature for each chemical (if more than one sample concentration available, the minimum sample concentration associated with the signature is used) is summarized by the minimum concentration associated with the signature in micromolar concentration units or NA if the signature was not indicated. 31 PFAS and 4 reference immunosuppressants demonstrated the immunosuppression signature. DTXSID, DSSTox Substance Identifier; QC, summarization of analytical QC results for the chemical.
| DTXSID | Chemical name | Molecular weight (g/mol) | QC | Acute toxicity | Immunosuppression | Liver toxicity | Organ toxicity | Skin irritation | Skin rash | Skin sensitization | Thrombosis | Vascular toxicity | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | DTXSID80375107 | 11:1 Fluorotelomer alcohol | 600.118 | P | NA | 0.4 | NA | 0.4 | 0.4 | NA | NA | NA | NA |
| 2 | DTXSID0020365 | Cyclosporin A | 1202.635 | N/A | 18 | 0.7 | NA | 0.7 | NA | NA | 6 | NA | NA |
| 3 | DTXSID3047429 | Dexamethasone sodium phosphate | 516.41 | N/A | NA | 1.5 | NA | NA | NA | NA | 1.5 | NA | 1.5 |
| 4 | DTXSID4020822 | Methotrexate | 454.447 | N/A | NA | 1.5 | NA | 40 | NA | NA | NA | NA | NA |
| 5 | DTXSID5060986 | 1H,1H,5H,5H-Per- fluoro-1,5-pentanediol diacrylate | 320.187 | P | 60 | 2.2 | NA | 2.2 | NA | NA | 20 | NA | NA |
| 6 | DTXSID80379721 | 1H,1H,6H,6H-Per-fluorohexane-1,6-diol diacrylate | 370.195 | P | 60 | 2.2 | NA | 2.2 | NA | NA | NA | NA | NA |
| 7 | DTXSID1 0224331 | 2,2,3,3-Tetrafluoro-propyl acrylate | 186.106 | P | NA | 2.2 | NA | 2.2 | NA | NA | 2.2 | NA | NA |
| 8 | DTXSID7060332 | (Perfluorobutyryl)-2-thenoylmethane | 322.2 | P | 60 | 2.2 | NA | 6.7 | NA | NA | 20 | NA | NA |
| 9 | DTXSID40108559 | Ammonium per-fluoro-2-methyl-3-oxa-hexanoate | 347.084 | N/A | NA | 2.2 | NA | 2.2 | 2.2 | NA | NA | 2.2 | NA |
| 10 | DTXSID4020119 | Azathioprine | 277.26 | N/A | NA | 4.2 | NA | 13 | NA | NA | 4.2 | NA | NA |
| 11 | DTXSID40380797 | 1H,1H-Perfluoro-3,6,9-trioxadecan-1-ol | 398.076 | F | 60 | 6.7 | NA | 20 | NA | NA | NA | NA | NA |
| 12 | DTXSID00194615 | 1H,1H,9H-Perfluoro-nonyl acrylate | 486.152 | P | NA | 6.7 | NA | 6.7 | NA | NA | 2.2 | NA | NA |
| 13 | DTXSID50382621 | 7:3 Fluorotelomer alcohol | 428.141 | P | 60 | 6.7 | NA | 6.7 | NA | NA | NA | NA | NA |
| 14 | DTXSID6027426 | 2-Perfluorooctyl-sulfonyl-N-ethylamino-ethyl alcohol | 571.25 | P | 60 | 6.7 | 60 | 2.2 | NA | NA | 20 | 6.7 | 6.7 |
| 15 | DTXSID80371164 | Perfluoro(2-(2-propo xypropoxy)-1H, 1H-propan-1-ol) | 482.093 | F | 20 | 6.7 | NA | 6.7 | NA | NA | NA | NA | NA |
| 16 | DTXSID90190949 | 1,6-Diiodoperfluoro-hexane | 553.856 | P | 20 | 20 | NA | 6.7 | NA | NA | NA | NA | NA |
| 17 | DTXSID5059799 | 1H,1H-Perfluorooctyl acrylate | 454.135 | P | NA | 20 | NA | 20 | NA | NA | NA | NA | NA |
| 18 | DTXSID1068772 | 2-(Perfluorobutyl)ethyl acrylate | 318.139 | P | NA | 20 | NA | 6.7 | NA | NA | 60 | NA | NA |
| 19 | DTXSID20874028 | 2H,2H,3H,3H-Per-fluorooctanoic acid | 342.108 | P | NA | 20 | NA | NA | NA | 2.2 | 6.7 | NA | NA |
| 20 | DTXSID30170109 | 3,3-Bis(trifluoromethyl)-2-propenoic acid | 208.059 | P | NA | 20 | NA | 20 | NA | NA | 6.7 | NA | NA |
| 21 | DTXSID70379295 | 3H-Perfluoro-2,2,4,4-tetrahydroxypentane | 262.08 | F | NA | 20 | NA | 20 | 60 | NA | 20 | NA | 60 |
| 22 | DTXSID1067629 | N-Methylperfluoro-octanesulfonamide | 513.17 | P | NA | 20 | NA | 20 | NA | NA | 6.7 | NA | 60 |
| 23 | DTXSID60400587 | Nonafluoropentana-mide | 263.063 | P | NA | 20 | NA | NA | NA | NA | NA | NA | NA |
| 24 | DTXSID60238701 | Perfluoropinacol | 334.061 | ND | 60 | 20 | NA | 6.7 | 6.7 | NA | NA | NA | NA |
| 25 | DTXSID9061881 | 1-Iodo-1H,1H,2H,2H-perfluoroheptane | 423.996 | P | NA | 60 | NA | 20 | NA | NA | NA | NA | NA |
| 26 | DTXSID50184723 | 1H,1H-Perfluoro-octylamine | 399.103 | ND | NA | 60 | NA | NA | NA | NA | NA | NA | NA |
| 27 | DTXSID1047578 | 1H,1H,2H,2H-Per-fluorohexyl iodide | 373.988 | P | NA | 60 | NA | NA | NA | NA | NA | NA | 60 |
| 28 | DTXSID50369896 | 1H,1H,10H,10H-Per-fluorodecane-1,10-diol | 462.13 | P | 60 | 60 | NA | 2.2 | NA | NA | 20 | NA | NA |
| 29 | DTXSID00380798 | 1H,1H,11H,11H-Per-fluorotetraethylene glycol | 410.112 | P | NA | 60 | NA | 2.2 | 20 | NA | 20 | NA | NA |
| 30 | DTXSID00190950 | 6:1 Fluorotelomer alcohol | 350.079 | P | NA | 60 | 60 | 60 | NA | NA | 60 | NA | NA |
| 31 | DTXSID5044572 | 3,3,4,4,5,5,6,6,7,7,8,8, 8-Tridecafluorooctanol | 364.106 | P | NA | 60 | 60 | 20 | 60 | NA | NA | NA | NA |
| 32 | DTXSID3066215 | (Heptafluorobutanoyl) pivaloylmethane | 296.185 | P | NA | 60 | NA | 20 | 60 | NA | 2.2 | NA | NA |
| 33 | DTXSID8031863 | Perfluorononanoic acid | 464.078 | P | 60 | 60 | 60 | NA | NA | NA | 2.2 | NA | NA |
| 34 | DTXSID70381151 | Perfluorooctanamidine | 412.102 | P | 60 | 60 | NA | 20 | NA | NA | 20 | NA | NA |
| 35 | DTXSID8051419 | Perfluorooctanesulfonamido ammonium iodide | 726.23 | P | NA | 60 | NA | 60 | NA | NA | 6.7 | 60 | NA |