Table 1. Clinical characteristics of patients with DLBCL older than 70 years according to serum albumin level.
| Characteristics | Total | Serum albumin | P value* | |
|---|---|---|---|---|
| Low (n=76) | High (n=20) | |||
| Sex | 1 | |||
| Male | 62 (64.6) | 49 (64.5) | 13 (65.0) | |
| Female | 34 (35.4) | 27 (35.5) | 7 (35.0) | |
| Age (years) | 0.012 | |||
| <80 | 61 (63.5) | 43 (56.6) | 18 (90.0) | |
| ≥80 | 35 (36.5) | 33 (43.4) | 2 (10.0) | |
| Cell of origin | 0.534 | |||
| Non-GCB | 64 (66.7) | 49 (64.5) | 15 (75.0) | |
| GCB | 32 (33.3) | 27 (35.5) | 5 (25.0) | |
| B symptoms | 0.214 | |||
| Absent | 58 (60.4) | 43 (56.6) | 15 (75.0) | |
| Present | 38 (39.6) | 33 (43.4) | 5 (25.0) | |
| Ann Arbor stage | 1 | |||
| I/II | 24 (25.0) | 19 (25.0) | 5 (25.0) | |
| III/IV | 72 (75.0) | 57 (75.0) | 15 (75.0) | |
| ECOG PS | 0.269 | |||
| 0, 1 | 40 (41.7) | 29 (38.2) | 11 (55.0) | |
| ≥2 | 56 (58.3) | 47 (61.8) | 9 (45.0) | |
| IPI | 0.123 | |||
| 1–2 | 27 (28.1) | 20 (26.3) | 7 (35.0) | |
| 3 | 26 (27.1) | 18 (23.7) | 8 (40.0) | |
| 4–5 | 43 (44.8) | 38 (50.0) | 5 (25.0) | |
| NCCN-IPI | 0.209 | |||
| 1–3 | 25 (26.0) | 18 (23.7) | 7 (35.0) | |
| 4–6 | 54 (56.2) | 42 (55.3) | 12 (60.0) | |
| 7–9 | 17 (17.7) | 16 (21.1) | 1 (5.0) | |
| ALB (g/dL) | 3.6±0.54 | 3.41±0.42 | 4.33±0.18 | <0.001 |
| AGR | 1.3±0.3 | 1.2±0.3 | 1.6±0.3 | <0.001 |
| Hemoglobin (g/L) | 114.3±22.0 | 111.5±21.8 | 125.1±19.6 | 0.013 |
| Ki-67 index (%) | 65.7±15.8 | 65.3±15.8 | 67.2±16.0 | 0.643 |
| Chemotherapy | 0.511 | |||
| Absent | 17 (17.7) | 15 (19.7) | 2 (10.0) | |
| Containing | 79 (82.3) | 61 (80.3) | 18 (90.0) | |
| Anthracycline | 0.385 | |||
| Absent | 23 (24.0) | 20 (26.3) | 3 (15.0) | |
| Containing | 73 (76.0) | 56 (73.7) | 17 (85.0) | |
| Rituximab | 0.657 | |||
| Absent | 32 (33.3) | 24 (31.6) | 8 (40.0) | |
| Containing | 64 (66.7) | 52 (68.4) | 12 (60.0) | |
| aCCI | 0.51 | |||
| 5–7 | 80 (83.3) | 62 (81.6) | 18 (90.0) | |
| 8–10 | 16 (16.7) | 14 (18.4) | 2 (10.0) | |
| NLR | 3.3 (2.4, 5.7) | 4.0 (2.5, 6.2) | 2.6 (1.9, 3.1) | 0.016 |
| LDH (U/L) | 252.0 (216.0, 409.8) | 252.0 (219.0, 427.2) | 252.0 (214.2, 294.0) | 0.381 |
For each variable, mean ± standard deviation, median (interquartile range), or number (percent) was reported (as appropriate). *, high serum albumin group vs. low serum albumin group. GCB, germinal center B-cell-like; ECOG PS, Eastern Cooperative Oncology Group performance status; IPI, International Prognostic Index; NCCN-IPI, National Comprehensive Cancer Network-IPI; AGR, albumin to globulin ratio; NLR, neutrophil-to-lymphocyte ratio; ALB, albumin; aCCI, age-adjusted Charlson Comorbidity Index; LDH, lactate dehydrogenase.