Fig. 6. Schematic depiction of different self-assembled strategies onto biomaterials surfaces. (a) Scheme illustration of the preparation of PDMS substrates having the similar stiffness as a healthy heart tissue and a well-defined surface chemistry obtained by conventional [(3-aminopropyl) triethoxysilane (APTES) and octadecyltrimethoxysilane (OTS)] and amino acid (histidine and leucine)-conjugated SAMs. (b) Scheme illustration of the supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to regulate cell adhesion behaviour. (c) Schematic of the modular composition of the AM-ELR and production of the AMP/ELR/AMELR self-assembled monolayers (SAMs) on gold surfaces. (d) Schematic illustration of dual-functional polyetheretherketone surface with an enhanced osteogenic capability and an antibacterial adhesion property in vitro by chitosan modification. These are reprinted with permission from Öztürk-Öncel et al. (2021, ACS Biomater. Sci. Eng.), Yeung et al. (2022, ACS Appl. Mater. Interfaces), Acosta et al. (2019, ACS Biomater. Sci. Eng.), Qiu et al. (2022, Langmuir), respectively.