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. 2023 Jul 10;13(30):20495–20511. doi: 10.1039/d3ra02248j

Coating strategies used for the generation of multifunctional surfaces.

Reference Methods Substrates Cell experiments/microorganisms Biocompatibility/bioactivity/antibacterial activity
27 N-hydroxysuccinimide (NHS) esterandmaleimide functionalities, chitosan, growth factor protein (FGFr2) molecules Tissue culture polystyrene (TCPS) Adipose-derived stem cells (ADSCs) Cellular spheroids exhibit an enhanced growth activity in terms of size (210% larger) and number (180% less spheroids) ADSCs cell growth activity and proliferation were enhanced
29 Fe-NP, hydrogel Metallic stent Human umbilical cord vein endothelial cells (HUVEC) Promoting endothelial cell adhesion, proliferation, and migration
30 Tricalcium phosphate (β-TCP), silver–silica (Ag/SiO2) nanocomposite NiTi shape memory alloy E. coli, Staphylococcus aureus (S. aureus), Saccharomyces cerevisiae (S. cerevisiae) The coating with silver doped inhibits organization of biofilm created by Gram-negative bacteria, antimicrobial activity, E. coli viability decreased, non-cytotoxic
31 Doxorubicin (DOX), polydopamine (PDA), 2-methacryloyloxyethyl phosphorylcholine (MPC) Intraocular lens (IOL) Human lens epithelial cell line (HLE B3, CRL-11421) The cell viability on the drug-loaded coating, surfaces decreased to around 40 or 20%, favorable biocompatibility, the excellent hydrophilicity
33 Antimicrobial peptides (AMP), diacrylate pluronic F127 (DAF127) hydrogel Polydimethylsiloxane (PDMS) S. Epidermidis, S. aureus Significant reduction in the surface-adhered bacteria counts, up to 99.3% reduction of S. epidermidis, antibacterial activity of 99.1% against S. aureus
34 Polydopamine, (PDA), gentamycin sulfate (GS) Poly(2-phenoxyethyl methacrylate-co-2-phenoxyethyl acrylate-co-2-ethylhexyl methacrylate) (PPPE) Human lens epithelial cells (HLECs) S. aureus, P. aeruginosa Antibacterial adhesion rates of 63.8%, 73.7% against S. aureus and P. aeruginosa respectively, biofilm formation was effectively inhibited, cell viabilities of HLECs were above 90%
35 α-Cyclodextrin (α-CD), chlorin e6, poly(poly(ethylene glycol)methacrylate) (PPEGMA) IOL HLE B3, CRL-11421 Excellent biocompatibility, increased cell adhesion and proliferation