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. 2023 Jul 10;13(30):20495–20511. doi: 10.1039/d3ra02248j

Covalent grafting strategies used for the generation of multifunctional surfaces.

Reference Surface functional groups Substrates Cell experiments Biocompatibility/bioactivity
45 Grafted polyvinylpyrrolidone (PVP) Polyvinyl chloride (PVC) medical catheters E. coli Fouling resistance of 99.98% against E. coli
Good compatibility
High surface hydrophilicity
58 Poly(ethylene glycol) (PEG), antithrombotic peptide ACH11 Au substrates Platelet Excellent hydrophilic property
Strong antiprotein and antiplatelet attachment ability
Excellent hemocompatibility
Inhibiting granulation formation and fibrous capsule
59 Ploy(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA)) Silicon, glass, titanium, stainless steel, and polymers Human blood cells, fibroblast cells, E. coli Reduced by 89.3%, 73.7%, 76.5%, 77.9%, and 49.6%, for platelet adhesion and by 96.1%, 96.2%, 83.7%, 88.1%, and 87% for erythrocyte adhesion with the surfaces respectively
A high reduction in human fibroblast (HT1080) adhesion of 96.3%, 96.5%, 91.3%, 86.3%, and 57.8% respectively
The high reduction in bacterial attachment of 88.5%, 79.7%, 86.9%, 90.8%, and 51.4% respectively
60 N,N-Dimethylacrylamide (DMAAm) Liposomes N/A Increased in surface softness
63 3-Aminopropylmethacrylamide (APMA), poly(ethylene glycol) methacrylate (PEGMA) Poly(d,l-lactic acid) (PLA) Human immortalized mesenchymal stem cell (hiMSCs), cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) Non-cytotoxic to hiMSCs
The size and number of hiMSC
Aggregates formed are primarily influenced by the surface chemistry of the incorporated microparticles